Effect of homeopathy in the function and morphology of salivar parotid glands of irradiated rats

Phillipe Nogueira Barbosa Alencar, Luiza Lassi de Araújo Lopes, Francisco Haiter Neto, Paulo Cesar Venancio, Francisco Carlos Groppo, Gabriella Lopes de Rezende Barbosa, Paulo Goberlânio de Barros Silva, Rafael Linard Avelar

Resumo


Objective: To evaluate the radioprotective effect of a homeopathic solution in salivary function and in parotid glands morphology of irradiated rats. Materials and Methods: The sample consisted of 150 rats randomly divided in 6 groups. The groups were named based on the substance administered: Control- saline solution; Irradiated Control- saline solution and 15 Gy of X radiation; Alcohol-hydroalcoholic solution dynamized at 15 CH; Irradiated Alcohol- hydroalcoholic solution dynamized at 15 CH and 15 Gy of X radiation; Homeopathy- 0.25 ml (1mL/kg) of the irradiated hydroalcoholic solution and dynamized at 15 CH; Irradiated homeopathy- homeopathic solution and 15 Gy of X radiation. Each group was subdivided in 5 different subgroups, based on the time point of euthanasia: 12 hours, 3, 10, 17, and 24 days. The medication was administered for 7 days before and 7 days after the radiation treatment. On the day of euthanasia, salivation was induced with pilocarpine and collected. The animals were then sacrificed and the parotid glands were removed. Results: Salivary function analysis showed that only group irradiated homeopathy euthanized on day 17 had a statistical significant difference when compared to other irradiated groups, presenting a higher salivation flow rate. The only group that showed statistical significant difference in the number of acini over the time was the irradiated alcohol group, which presented a tendency of reduction. Conclusion: The homeopathic solution presented a late radioprotective effect based on salivary function and morphological analysis of the parotid gland.


Palavras-chave


Radiotherapy; Homeopathy; Salivary Glands.

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DOI: http://dx.doi.org/10.12662/2317-3076jhbs.v8i1.2993.p1-6.2020

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