Severe Kala-azar and seric level of IL-6: case reports

Gilmara da Rocha Brito, Aécio da Silva Marreiros, Izael Francisco de Brito Araujo, Raimundo Gerônimo da Silva Júnior, Ingridi de Souza Sene, Débora Cavalcante Braz


Introduction: IL-6 cytokine participates in the inflammatory process of systemic leishmaniasis and elevated levels are associated with active disease. Case reports: Three patients with different age groups and different severity scores, above 4 were reported, and IL-6 plasma concentrations and their association with disease severity were observed. Conclusion: Analysis suggests that only the score, has no sensitivity to classify, among others critically ill patients, those with imminent risk of death. IL-6 concentrations can allow this differentiation, considering that only fatal case, HBV/Leishmania coinfection, presented expressively higher level of the cytokine concentration.


Calazar, Interleucina-6, Coinfecção, Hepatite B

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Direitos autorais 2020 Journal of Health & Biological Sciences

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