Rhino-orbital mucormycosis in a diabetes patient with renal impairment after amphotericin B deoxycholate: the role of amphotericin B lipid-complex treatment

Italo Gustavo Lima Monteiro, Luis Arthur Brasil Gadelha Farias, Ruth Maria Oliveira de Araújo, Licia Borges Pontes

Resumo


Introduction: Mucormycosis is an infection caused by the ubiquitous saprophyte fungi with rapid and aggressive progression, especially in immunocompromised patients. Case report: A 57-year-old woman diagnosed with rhino-orbital mucormycosis presented with decreased renal function after treatment with amphotericin B deoxycholate which was discontinued. Renal function improved after amphotericin B lipid-complex, being also treated with itraconazole, and otorhinolaryngological surgery. Conclusion: The use of Amphotericin B deoxycholate may result in adverse effects. In this situation, Amphotericin B lipid formulation is usually the drug of choice.

Palavras-chave


Mucormycosis; Amphotericin B; Liposomal Formulation; Drug Therapy

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DOI: http://dx.doi.org/10.12662/2317-3076jhbs.v9i1.3545.p%25p.2021

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Direitos autorais 2021 Journal of Health & Biological Sciences

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