Psychosis in Huntington´s Disease. a rare and Under-Investigated Psychiatric Manifestation

Maria João Gonçalves, Carla Ferreira, Rodrigo Saraiva, Carolina Sereijo, Lígia Castanheira, Elsa Fernandes, Rita Amaro, Tiago Mendes, Leonor Correia Guedes, Manuela Abreu, Inês Chendo


Introduction: Psychotic symptoms are among the least prevalent and under-investigated psychiatric manifestations (PM) of Huntington's disease (HD). Case report: We herein report a case of a 31-year-old male patient who presented PM with a predominance of negative symptoms, without any significant abnormal movement. HD was diagnosed based on positive DNA analysis and family history. HD imposes longitudinal follow-up through a multidisciplinary approach in order to improve the quality of life and prognosis. Conclusion: This case report highlights the importance of comprehending the PM in the initial presentation of HD so that the diagnosis is not delayed until the onset of motor symptoms.


Huntington's disease; Psychosis Psychiatric Manifestation; Negative Symptoms

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Direitos autorais 2021 Journal of Health & Biological Sciences

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