Anxiolytic and antidepressant effects of cannabidiol: a systematic review

José Eduardo Ribeiro Honório Júnior, Jessica Rodrigues de Morais Barriga, Dara da Silva Mesquita, Joel Porfírio Pinto


Objetctive: Realize a systematic review on articles about cannabidiol (CBD) as an anxiolytic and antidepressant drug. Methodology: A systematic review in PubMed, Science Direct and PsycINFO databases taking into consideration articles published in English and Portuguese from 2008 to 2018 with animal experimentation. Results: Eleven articles with experimental studies on animals were included. All studies exhibited anxiolytic and antidepressant activities after CBD use. Conclusion: It was proven by several experiments the anxiolytic and antidepressant activity of CBD, however there is still a need of more preclinicals and clinicals studies to elucidate its mechanisms.


Cannabis; Cannabidiol; Anxiolytic; Antidepressant

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Direitos autorais 2021 Journal of Health & Biological Sciences

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