Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records
DOI:
https://doi.org/10.12662/2317-3076jhbs.v9i1.3864.p1-8.2021Keywords:
Breast Neoplasms, Antineoplastic Agents, ToxicityAbstract
Objective: To evaluate the occurrence of hematological and functional toxicities during chemotherapy with doxorubicin and cyclophosphamide in women with breast invasive ductal carcinoma. Methods: This was a descriptive, cross-sectional and quantitative study, involving the data collection in clinical records of 119 women undergoing chemotherapy for breast invasive ductal carcinoma in an oncology outpatient clinic, carried out between February 2014 and February 2015. Results: The investigated toxicities and their respectively occurrences in patients exposed to doxorubicin and cyclophosphamide were hemoglobinemia (26,5%), leukopenia (21,6%), neutropenia (10,8%), thrombocytopenia (none) and reduced hematocrit (28,4%), in addition to fatigue (93,1%), fever (20,6%), gain (35,3%) and weight loss (22,5%). In these variables, there were no significant differences between the exposed and not exposed patients. The association with taxanes showed a significant reduction in hematocrit values (p=0.019) and the toxicities distributed by age group were not significant within the exposed group. Conclusions: Exposure to doxorubicin and cyclophosphamide was not associated with an increase in the occurrence of hematotoxicities and functional impacts in women with breast ductal invasive carcinoma, except when associated with taxane agents.Downloads
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
a) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Declaration
Transfer of Copyright
The author hereby declare that the article entitled "TITLE OF THE ARTICLE" approved for publication in the Journal of Health & Biological Sciences is an original work that has not been published or is being considered for publication elsewhere, that is in print or electronic.
The author's manuscript quoted above also states (m):
- I certify that I have participated sufficiently in the work to take public responsibility for the content.
- I declare that the use of any trademark or copyright in the manuscript has been credited to its owner or permission to use the name was given, if necessary.
- I declare that I agree that the copyright for the article referenced above will become the exclusive property of the Journal of Health & Biological Sciences - JHBS, any form of reproduction, in whole or in part, in any form or means of disclosure, printed or electronic, without the prior authorization is required, and, if obtained, I include my thanks to the Journal of Health & Biological Sciences - JHBS.
- The original submission to the Journal of Health and Biological Sciences (JHBS) imply transfer by authors, printed and digital publishing rights.
Note: All persons listed as authors must sign this statement and signed statements will not be accepted by others.
The original statement shall be signed, dated and sent to the address below or by email:
JOURNAL OF BIOLOGICAL SCIENCES & HEALTH
Councilman Paul Street Mamede, 130 - 5th floor - Neighborhood: Coco.
Fortaleza - CE
CEP 60192-350
Phone: (85) 3265-8109, Ext: 8109
e-mail: @ secretaria.jhbs fchristus.edu.br