EVALUATION OF INTERACTIONS OF SILIBININ WITH THE PROTEINS ALS3 AND SAP5 AGAINST Candida albicans

Authors

  • Cecília Rocha da Silva School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Francisca Lariza Damacieira Moura Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • André Luis Almeida Alves Filho Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • Rosana de Sousa Campos Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • Vitória Pessoa de Farias Cabral School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Lívia Gurgel do Amaral Valente Sá School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Anderson Ramos da Silva Department of Surfactants and Nanobiotechnology, IQAC-CSIC, Barcelona, Spain.
  • Jacilene Silva Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, , Ceará, Brazil.
  • Akenaton Onassis Cardoso Viana Gomes Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • Letícia Bernardo Barbosa Christus University Center http://orcid.org/0000-0003-0276-711X
  • Hélcio Silva dos Santos Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, , Ceará, Brazil.
  • Emmanuel Silva Marinho Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, , Ceará, Brazil.
  • Bruno Coelho Cavalcanti Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Hélio Vitoriano Nobre Júnior School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • João Batista De Andrade Neto School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.

DOI:

https://doi.org/10.12662/2317-3076jhbs.v10i1.4239.p1-6.2022

Abstract

Introduction: Fungi of the genus Candida spp. are responsible for most invasive fungal infections. The number of clinical isolates resistant to antifungals like fluconazole is growing. In this context, herbal medicines are being studied for use alone or in combination with other drugs as alternatives to treat these infections. Among them is silibinin, a silymarin compound extracted from Silybum marianum, which has a wide range of therapeutic properties, such as anti-inflammatory, anti-fibrotic, hepatoprotective and antioxidant, as well as synergism with some antibiotics. Objective: To evaluate the molecular interaction of silibinin with the targets ALS3 and SAP5. Methodology: Molecular docking protocols were conducted to analyze the binding interaction of silibinin with ALS3 and SAP5. Results: Eleven interactions of ALS3 with silibinin and four with fluconazole were found, while six interactions were observed of SAP5 with silibinin and four with fluconazole. Conclusion: Molecular docking between silibinin and ALS3 identified important interactions, but no significant interactions were observed with SAP5, even though silibinin can exhibit affinity and interactions with other SAP5 sites.

 

Keywords: Silibinin, Fungal Infection, Candida spp., Molecular Docking, Adhesion Proteins.

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Published

2022-06-01

How to Cite

1.
da Silva CR, Damacieira Moura FL, Almeida Alves Filho AL, Campos R de S, Cabral VP de F, Valente Sá LG do A, et al. EVALUATION OF INTERACTIONS OF SILIBININ WITH THE PROTEINS ALS3 AND SAP5 AGAINST Candida albicans. J Health Biol Sci. [Internet]. 2022 Jun. 1 [cited 2024 Jul. 22];10(1):1-6. Available from: https://periodicos.unichristus.edu.br/jhbs/article/view/4239

Issue

Vol. 10 No. 1 (2022): Journal of Health and Biological Sciences

Section

Original articles

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