Evaluation of interactions of silibinin with the proteins ALS3 and SAP5 against Candida albicans

Autores/as

  • Cecília Rocha da Silva School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules
  • Francisca Lariza Damacieira Moura Christus University Center (UNICHRISTUS)
  • André Luis Almeida Alves Filho Christus University Center (UNICHRISTUS)
  • Rosana de Sousa Campos Christus University Center (UNICHRISTUS)
  • Vitória Pessoa de Farias Cabral School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules
  • Lívia Gurgel do Amaral Valente Sá School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules
  • Anderson Ramos da Silva Department of Surfactants and Nanobiotechnology,
  • Jacilene Silva Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry
  • Akenaton Onassis Cardoso Viana Gomes Christus University Center
  • Letícia Bernardo Barbosa Christus University Center http://orcid.org/0000-0003-0276-711X
  • Hélcio Silva dos Santos Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE),
  • Emmanuel Silva Marinho Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE),
  • Bruno Coelho Cavalcanti Federal University of Ceará
  • Hélio Vitoriano Nobre Júnior Federal University of Ceará
  • João Batista De Andrade Neto School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN)

DOI:

https://doi.org/10.12662/2317-3076jhbs.v10i1.4239.p1-6.2022

Resumen

Objective: to evaluate the molecular interaction of silibinin with the targets ALS3 and SAP5. Methodology: Molecular docking protocols were conducted to analyze the binding interaction of silibinin with ALS3 and SAP5. Results: Eleven interactions of ALS3 with silibinin and four with fluconazole were found, while six interactions were observed of SAP5 with silibinin and four with fluconazole. Conclusion: Molecular docking between silibinin and ALS3 identified important interactions, but no significant interactions were observed with SAP5, even though silibinin can exhibit affinity and interactions with other SAP5 sites.

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Publicado

2022-06-01

Cómo citar

1.
da Silva CR, Damacieira Moura FL, Almeida Alves Filho AL, Campos R de S, Cabral VP de F, Valente Sá LG do A, et al. Evaluation of interactions of silibinin with the proteins ALS3 and SAP5 against Candida albicans. J Health Biol Sci. [Internet]. 1 de junio de 2022 [citado 18 de agosto de 2025];10(1):1-6. Disponible en: https://periodicos.unichristus.edu.br/jhbs/article/view/4239

Número

Vol. 10 Núm. 1 (2022): Journal of Health and Biological Sciences

Sección

ARTÍCULOS ORIGINALES

Licencia

Derechos de autor 2022 Journal of Health and Biological Sciences

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

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