Profile of polyomavirus infection in renal transplant patients on immunosuppressive therapy

a descriptive study at a university hospital in Fortaleza

Abstract

Objective: the main objective of this study was to compare the risk of BK virus infection in kidney transplant patients treated with two different therapeutic regimens. Furthermore, the influence of sociodemographic factors on the risk of virus infection between the two treatment groups was evaluated. Methods: we carried out research with data collected between 2019 and 2023 from electronic medical records in a university hospital in Fortaleza. Statistical analysis was performed using the JAMOVI software, using the chi-square test to evaluate the association between risk factors and BKV infection and the ANOVA and Student's T-test to evaluate the association between risk factors and BKV infection. average pace of internationalization. Results: statistical evaluation using the Student's T-test showed no significant differences in the length of stay between male and female patients (p>0.05), and the length of stay of patients was also not statistically related to the use of corticosteroids. In immunosuppressive therapy (p>0.05), positivity for BKV (p>0.05) and also not indifferent regarding the different immunosuppression regimens adopted (p>0.05). Statistical analysis with the chi-square test does not include a significant association between the immunosuppressants used and post-transplant BK virus infection. Conclusion: the prevalence of virus infection is much more related to the intensity of immunosuppression than the nature of the immunosuppressants used, highlighting the importance of monitoring serum levels.